In-vitro Tests of Topical Skin Protectants using a Flow-Through Diffusion Cell System Containing Excised Hairless Mouse Skin

Highly toxic chemical warfare agents(CWA) could be used in and terrorism. The protection of skin is crucial for civilians soldiers, because the primary routes exposure to CWA are inhalation absorption. Thus, topical protectants(TSP) have been studied developed many countries complement protective equipments. In this study, <i>in-vitro</i> test procedure was optimized established using a flow-through diffusion cell system containing excised hairless mouse an attempt assess effectiveness various TSP formulations against nerve agent simulants. addition, results on including ingredients SERPACWA(Skin Exposure Reduction Paste Against Chemical Warfare Agent) IB-1(TSP Israel) were included, indicating that with perfluorinated compounds more effective than glycerin-based formulations.